![]() ![]() ![]() The pharmacokinetic parameters and oral bioavailability of VP-16 suspension and VP-16 in SNEDDS was assessed using 30 Male Sprague–Dawley rats and compared with the commercial product (VePesid ®). Based on an obtained ternary phase diagram, an optimum formulation was selected and characterized in terms of size, zeta potential, loading, morphology and in vitro drug release. METHOD: A series of SNEDDS formulations with VP-16 were prepared consisting of medium chain triglycerides, polysorbate 80, diethylene glycol monoethyl ether and propylene glycol monolaurate type-1. PURPOSE: The purpose of this study was to investigate the ability of a self-nano-emulsifying drug delivery system (SNEDDS) to enhance the oral bioavailability of a BCS class IV drug, etoposide (VP-16). ![]() Institute of Pharmaceutical Science, Faculty of Life Sciences and Medicine, King’s College London, London, UK.įaculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canadįaculty of Pharmacy, Margalla Institute of Health Sciences, Rawalpindi, Pakistan. Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.įaculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Punjab, Pakistan.Ĭollege of Pharmacy, Al Ain University of Science and Technology, Al Ain, Abu Dhabi, UAE.
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